Grehan, 23, has been named in the centres for the game at Huntington Stadium, with the winner taking home the Paul Higgins Memorial Trophy.
Tigers head of youth development Steve Gill said: “Paul Higgins was a fantastic servant to both clubs in the 80’s and it is only fitting that both clubs pay tribute to the Paul Higgins 13 Trust, which was put into place to help develop young Rugby League players around the York and District area.
“York City Knights have paid our young guys the ultimate compliment by announcing a full strength side for this fixture, so we will be really tested before we enter our first league game against Salford the following week.
“It will also be nice to see trialist Aston Wilson and new signing James Grehan in action – both are named in the centres -, and also the welcome return of York-based centre/back row Sam Orange who missed large parts of last year with injuries.
“The lads had a comfortable win last week at Gateshead Thunder where we played 6 of our under 18s squad, but the bar has been lifted quite considerably for this fixture and we are looking forward to the challenge.”