The match will be the third Challenge Cup Final for the 39-year-old, who also officiated in the 2008 Wembley final between St Helens and Hull FC and the 2005 final between Leeds Rhinos and Hull FC at Millennium Stadium, Cardiff.
“I feel very privileged to be given the opportunity to referee the final and am looking forward to Wembley immensely,” said Ganson.
“During my career I have refereed in many big games, including internationals, Grand Finals and World Club Challenges, but the Challenge Cup Final is something special.
“Like many people, some of my earliest of Rugby League involve Wembley and I know how important this fixture is.
“What is also important is that as a team of match officials we all go out there on Saturday and put in a good performance.”
The touch-judges at Wembley will be Tony Martin and Clint Sharrad, the video referee will be Phil Bentham and the match commissioner Dave Campbell.
The reserve referee is Richard Silverwood with Richard Cowling is the reserve touch-judge.