Wigan winger Josh Charnley crossed for a quartet of tries as Wales‘ involvement in the Autumn International Series came to an abrupt end.
The hosts held out for the first nine minutes, albeit after Kallum Watkins had a second minute try disallowed, until Ryan Hall exposed a narrow defence to touchdown on the left.
When Charnley and Leeds full back Zak Hardaker, making his international debut, went over for quickfire tries shortly after, the writing was well on the wall.
Watkins, also on debut, scored a try and Hardaker’s second put England 26-6 up at the interval, with the hosts getting on the scoresheet courtesy of Christian Roets on the hooter.
Hall, recently named as the best winger in the world, grabbed his second early in the second half, before Dan Fleming took advantage of some soft English defence to register Wales‘ second, and last, try.