Lee Hudson and Joe Bate have left North Wales because of family and work commitments respectively.
Hudson is currently third on the list of all-time club appearances, having played 123 games.
The 28-year-old has been with North Wales since the club originally formed back in late 2011, spending seven full seasons in Wrexham.
Bate has also left the club with immediate effect because of work commitments.
A Crusaders spokesperson said: “The club would like to wish Lee all the best in the future and thank him for his loyal service since 2012.
“Thank you for your efforts in a Crusaders shirt, Joe.”