The Rhinos meet the Cowboys at Headingley on February 21, while St Helens take on the Roosters and Wigan play Brisbane.
“I’m really looking forward to it,” he told Love Rugby League.
“It’ll be interesting to see if the Cowboys can climatise when they get over here. It will be freaking hot over there.”
Cuthberton has played in the World Club Challenge once before, seven years ago when he was part of the Manly team that defeated the Rhinos 28-20 on UK soil.
The front-rower is expecting a hard contest against North Queensland, who feature Golden Boot winner Jonathan Thurston and rising Queensland Origin star Michael Morgan in the halves along with a host of internationals.
“It’ll be interesting,” Cuthbertson said.
“It’ll be great to play against an NRL team again and get this opportunity to play in another World Club Challenge.
“I’ve been in one before but it was ’09 I was last in one so, yeah it’s just a really great opportunity for us to display our brand of football throughout the world.”
Cuthbertson, who helped Leeds to a treble in his first year at the club, feels that Super League as a whole has a point to prove after the three losses in 2015.
“Not just speaking for those teams, but I’m sure there’s a bit of disappointment around Super League after going down three games to zip,” the 30-year old admitted.
“There’s a lot at stake and we’d like to show that we can handle anyone really.
“It’s just about is getting out there and playing our game to the best of our ability and executing really well, and taking it really to them.”