The game is part of a double header at the Halliwell Jones Stadium, which also sees the Wolves take on French side Toulouse at 1pm.
Clark, 21, switched from Castleford during the off-season on a four-year deal, and featured for England in the Four Nations Down Under in the autumn.
A number of players featuring in the Toulouse game will double-up and step on to the bench against Hull KR.
Squad v Toulouse: Matty Russell, Gene Ormsby, Toby King, Harvey Livett, Jack Johnson, Gary Wheeler, Declan Patton, Roy Asotasi, Andy Ackers, Anthony England, Ben Evans, Joe Philbin, Ben Harrison Subs: George King, Declan Kay, Daniel Murray, Robert Holroyd, Morgan Smith, Andy Philbin, Daniel Hirst, Sam Wilde.
Squad v Hull KR: Stefan Ratchford, Rhys Evans, Ryan Atkins, Joel Monaghan, Kevin Penny, Gareth O’Brien, Richie Myler, Chris Hill, Daryl Clark, Ashton Sims, James Laithwaite, Ben Currie, Ben Westwood. Subs: Chris Bridge, Micky Higham