The Panthers, the only unbeaten team in all three professional divisions, were ruthless from first to last against weakened opponents who singularly failed to cope with the absence of four players through suspension.
Blackpool scored 22 tries in all but amazingly had no hat-tricks in their total, which also featured 22 goals from Tom Hemingway, who also touched down once for a personal haul of 48 points.
Oldham completed the first win at their new home, Whitebank Stadium where London Skolars tumbled to a 46-12 defeat.
The win, which featured two tries for Lucas Onyango plus others for Martin Roden, Paul O’Connor, Danny Whitmore, Ben Heaton, Craig Robinson and John Gillam, keeps Oldham at the top of the Co-operative Championship One table.
Workington Town held off a strong second half fightback by Doncaster to win 34-20 at Derwent Park.
Doncaster hit back with two tries from Shaun Leaf plus others by Michael Butterfield and Chris Spurr but the Cumbrians held firm with further tries of their own by Liam Finch, Lee Dutton and Neil Frazer.
The Hawks led 22-10 at the halfway stage and held firm in a win which featured two tries for David March and others for Paul March, Waine Pryce, Tommy Haughey, Danny Grimshaw, Wayne McHugh and Dave Clayton.