The Warriors ran in 15 tries in an 84-6 thrashing of the Robins on Easter Monday, and return to Hull looking to secure a place in the quarter-finals.
The home side have only once beaten the 18-times winners in five meetings in the Challenge Cup.
Wigan are without scrum half Matty Smith, after he picked up a shoulder injury in last week’s win over Salford, so Sam Powell or Sean O’Loughlin will partner ex-Rovers man Blake Green at half-back. Pat Richards also returns to the squad.
Michael Dobson has been named in Craig Sandercock’s 19-man squad.
Wigan 19-man squad: Burke, Charnley, Crosby, Farrell, Flower, Goulding, Green, Hansen, Hughes, Lauaki, McIlorum, Mossop, O’Loughlin, Powell, Richards, Taylor, Thornley, L Tomkins, S Tomkins.
Hull KR 19-man squad: Salter, Caro, Walker, Green, Griffin, Paterson, Mika, Burns, Horne, Withers, Hall, Paea, Carlile, Lovegrove, Dobson, J Hodgson, Eden, Beaumont, D Hodgson.
Prediction: Hard to see Hull KR getting revenge for their league mauling – away win.
Previous Challenge Cup meetings:
1990 (Round 1) Hull KR 4 Wigan 6
1985 (Semi-Final) Hull KR 11 Wigan 18 (at Elland Road, Leeds)
1980 (Round 1) Wigan 13 Hull KR 18
1963 (Semi-Final) Hull KR 4 Wigan 18 (at Headingley, Leeds)
1953 (Quarter Final) Wigan 25 Hull KR 6
Hull KR 6 Wigan 84 (SLR10, 1/4/13)