The draw saw the entry of all 12 Kingstone Press Championship sides as they joined seven Kingstone Press League 1 teams and five National Conference League clubs in the pot.
Featherstone Lions overcame South Wales Scorpions 37-20 at the weekend, they will now have to carry on that form in an all National Conference League clash at home against Lock Lane in the next round.
The 2016 Ladbrokes Challenge Cup fourth round draw in full is as follows:
Batley Bulldogs v Whitehaven
Hunslet Hawks v Doncaster
Featherstone Lions v Lock Lane
Oldham v Kells
Pilkington Recs v Halifax
Toulouse Olympique XIII v University of Gloucestershire All Golds
Fourth round ties will be played over the weekend of March 19-20.