Holders St Helens will face Catalans Dragons in the fifth round of the Challenge Cup in a repeat of the 2007 final.
The only other Super League tie will take place between Wakefield and Wigan, who defeated Championship sides Leigh and Barrow in the fourth round respectively.
Struggling Salford will travel to Batley while Castleford host Halifax.
Warrington face a tricky tie at Featherstone and Hull KR play Sheffield.
Championship 1 side Rochdale travel to the Galpharm Stadium to face Huddersfield and the only all non-SL tie sees Gateshead play Oldham.
Games will be played on the weekend of May 9/10
Gateshead v Oldham
Batley v Salford
Castleford v Halifax
Featherstone v Warrington
St Helens v Catalans Dragons
Huddersfield v Rochdale
Hull KR v Sheffield
Wakefield v Wigan