Leeds will take on St Helens in the pick of the ties from the Challenge Cup fifth round draw.
Holders Wigan will host Championship One side Hunslet, while Warrington were also able to avoid Super League opposition, in the shape of Doncaster.
There were only two other all Super League ties, besides the one at Headingley – with Widnes travelling to Salford, and Bradford hosting Catalan.
Swinton host Keighley and Leigh face Featherstone in two all-Championship ties, while Castleford take on Sheffield.
The games will take place from 25-27 April.
Wigan Warriors v Hunslet Hawks
Leigh Centurions v Featherstone Rovers
Leeds Rhinos v St Helens
Warrington Wolves v Doncaster
Salford Red Devils v Widnes Vikings
Bradford Bulls v Catalan Dragons
Swinton Lions v Keighley Cougars
Castleford Tigers v Sheffield Eagles