Oldham full-back Richard Lepori returns after missing last week’s narrow defeat by Rochdale Hornets.
Lepori was on international duty with Italy, producing a man of the match display in their 32-20 win over Serbia.
Oldham have won seven of their last eight meetings with London Skolars, with their last defeat coming in July 2011.
Oldham coach Scott Naylor said: “I can never knock this fine young squad for effort and desire. They are a great bunch; gutsy, hard working and exceptionally fit.”
Skolars coach Joe Mbu faces a major reshuffle of his side’s attacking options after Dylan Skee, a nominee for the Kingstone Press Championship One Player of the Year award, broke his ankle late in the game against Hemel Stags last week.
Mbu said: “Dylan will definitely be missed, but he’ll be with us at the weekend and that’s the type of guy he is. The players want to do it for him.”
On Oldham, Mbu added: “They’re a good side but we’re a lot stronger team now than in our two previous meetings this year, and that puts me in a positive spirit.”