South Sydney forward Burgess, who will miss out on representing his country for the time since 2010, will have surgery after a routine scan revealed that the former Bradford Bulls star has a knee injury.
Atkins (shoulder) and Westwood (knee and groin) are also ruled out and will both undergo surgery following Warrington’s defeat to Leeds Rhinos in the Super League Grand Final at Old Trafford on Saturday.
The 24-man squad leave the United Kingdom on Wednesday October 10 for a 10-day high-altitude camp in Potchefstroom, South Africa before travelling back for the Autumn International Series.
The Autumn International Series concludes with the final at Salford City Stadium on Sunday November 11 (5.00pm).
Tickets for the 2012 Autumn International Series cost just £12 for adults and £6 concessions and can be purchased by calling the RFL Ticket Office on 0844 856 1113 or by visiting www.rugbyleaguetickets.co.uk