Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
The rugby league rumour column that doesn't disappoint.
Huddersfield back-rower Tom is preparing himself for a tough contest with an in-form Hull FC forward pack tomorrow night.
London coach Andrew Henderson says the Broncos won't be making "panic buys" to strengthen its ahead of the Super 8s.
Huddersfield coach Andy Kelly was delighted to see his side put in an impressive defensive display on the way to victory against Hull FC.