Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
Hull KR hooker John Boudebza has been suspensed for four matches for his tackle on Castleford centre Michael Shenton.
After an interesting first round of matches in European rugby league’s second tier, we take a look at some of the biggest highlights of the weekend.
Huddersfield hooker Luke Robinson has been forced to retire because of a hip injury.
Hooker Adam Milner has signed a two-year contract extension that will keep him at Castleford until the end of the 2018 campaign.
Ryan Lannon has signed a new three-year contract with Salford that ties him to the club until the end of 2018.