Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
Salford centre Junior Sa’u is excited about the new season and believes the Red Devils are heading in the right direction, with Tim Sheens at the helm as director of rugby.
Daryl Powell believes the decision to not use any Castleford players in the recent Internationals can be used as a motivator for next season.