Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
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Huddersfield assistant coach Kieron Purtill will join Leigh's coaching staff at the end of the current season on a two-year contract.
Salford's appeal against its six-point deduction for salary cap infringements will be heard by independent body Sport Resolutions.