Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
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Iestyn Harris could be in the last days of his tenure as Salford Red Devils coach, with the 39-year-old unlikely to take charge of his team's forthcoming game against Catalans.
Widnes coach Denis Betts has asserted that the club's takeover of the running of the Cumbrian Regional Academy will provide plenty of young players with the chance to reach Super League.