Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
Leeds coach Brian McDermott believes that his back row unit were the key men when it came to winning the Challenge Cup final at Wembley on Saturday.
John Davidson reflects on a weekend at Wembley where Leeds Rhinos made history in stunning fashion in the capital.